EFFICACY OF MONOTHERAPY VERSUS COMBINATION THERAPY IN MODERATE HYPERTENSION
DOI:
https://doi.org/10.47144/phj.v37i1-2.75Keywords:
VERSUS COMBINATIONAbstract
This prospective study was conducted to ascertain the difference in efficacy of a long term ACE inhibitor,Ramipril, used alone and in combination with a dihydropyridine calcium antagonist, amlodipine, in
moderate hypertension. The patients were free from long term complications of hypertension. This study
included 60 patients aged 25-62 years (42males , 18 females ) with essential hypertension, stage II i.e. systolic
B.P ³160 mmHg and diastolic B.P³100mmHg (JNCVI ). Two groups of patients were formed, group A
included patients treated with Ramipril alone and group B included patients treated with combination of
Ramipril and amlodipine over a period of six weeks. The study showed a prominent decline in blood pressure
of patients in both groups, however target blood pressure was achieved and sustained more effectively in
group B .
It is concluded that in order to obtain a more stable drop in blood pressure, combination therapy is more
beneficial both in efficacy and cost effectiveness than monotherapy.
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1.
KHAN AA, INAYAT M. EFFICACY OF MONOTHERAPY VERSUS COMBINATION THERAPY IN MODERATE HYPERTENSION. Pak Heart J [Internet]. 2012May12 [cited 2024Nov.24];37(1-2). Available from: https://pakheartjournal1.pcs.org.pk/index.php/pk/article/view/75
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