ROLE OF ROSUVASTATIN PRETREATMENT IN PREVENTION OF CONTRAST INDUCED NEPHROPATHY IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY

Authors

  • Ahmed Abdul-Aziz ElTahawy
  • Basem Elsaid Enany
  • Mohsen Fahmy

DOI:

https://doi.org/10.47144/phj.v46i4.704

Keywords:

Contrast Induced Nephropathy, Rosuvastatin, Angiography

Abstract

Objective: The aim of this study was to assess the efficacy of short-term highdose
rosuvastatin pretreatment therapy for the prevention of contrast induced
nephropathy.
Methodology: This study prospectively included two hundred patients who
underwent coronary angiography, and were randomized into two groups: control
group (included 100 patients who did not receive statin therapy) and statin group
(included 100 patients who received rosuvastatin 20 mg/day 3 days before and 7
days after coronary angiography).According to recommendations of the National
kidney foundation, results had been recorded using both serum creatinine and
glomular filteration rate levels.
Results: There was statistically significant reduction in the occurrence of
contrast-induced nephropathy in rosuvastatin pretreated patients ("22%" and
"15%" of them developed contrast-induced nephropathy regarding the glomular
filteration rate and serum creatinine levels respectively), compared to those in the
control group ("35%" and "38%" regarding the glomular filteration rate and serum
creatinine levels respectively) with P-value (<0.001 regarding serum creatinine
and <0.042 regarding glomular filteration rate).
Conclusion: This study favors statin pretreatment for preventing contrast
induced nephropathy in patients undergoing coronary angiography.

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How to Cite

1.
ElTahawy AA-A, Enany BE, Fahmy M. ROLE OF ROSUVASTATIN PRETREATMENT IN PREVENTION OF CONTRAST INDUCED NEPHROPATHY IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY. Pak Heart J [Internet]. 2014May15 [cited 2024Nov.24];46(4). Available from: https://pakheartjournal1.pcs.org.pk/index.php/pk/article/view/704

Issue

Vol. 46 No. 4 (2013): Pakistan Heart Journal

Section

Original Article

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