Effect of Aspirin & Nicotinic Acid Derivative on Hyperlipo.. proteinemic Rabbits

Abstract

INTRODUCTION:

Human 16w-density lipoprotein (LDL) and high-density lipoprotein (HDL) are . two of  the major carriers of cholesterol in human blood. Plasma level of LDL has been suggested to have a direct correlation with the deposits of cholesterol in plaques on arterial walls and subsequent atherosclerosis.2’3 There appears to be a positive correlation between LDL and inverse relationship between HDL cholesterol and risk of developing coronary •artery disease.4’5 The cholesterol concentration of HDL represents approximately 25% of total serum cholesterol in normal ind ividuaLs and less than 20% in those with coronary artery disease.6’7.A wide variety of agents have been reported to be effective in hypercholesterolemic condition such as, Clofibrate, Nicotinic acid and its derivat ive etc.

MATERIAL AND METHODS:
All experiments are carried out on healthy rabbits weighing 1. 5-2.0 kg. Rabbits are classified into the following four groups, each group comprised of 4 rabbits: The details of the groups and their treatment with drugs has already been described elsewhere (Saify etal 1 O)• In brief for the determination of HDL cholesterol chemical kit (Cat No. 400971 and Cat No. 231347) and for LDL cholesterol chemical kit (Cat No. 124931) of Boehringer Mannheim was used.

RESULT:

Results are summarized in Table 1,2,3 and 4. Table 1 shows the level of serum HDL cholesterol (mg/100 ml) in all the 4 groups of rabbit before the treatment with dru, i.e., for 120 days.Nicotinic acid, derivative treated group (Grou pB) also shows a progressive decrease in serum HDL and LDL cholesterol level starting from the 5th day through .20th day though statistically not significant except on 15 and 20th days (<.01)

DISCUSSIONS:

The goal of serum lipid lowering in HLP is prevention of atherosclerosis éomplications. This effect is believed to operate through an influence on the serum lipoprotein levels of the developm ent of atheroma. The complications of the atherosclerosis may result, in acute myocardial infarction, angina pectoris, and sudden death. A more direct way of measuring the effect of the lipid lowering treatment would determine the concentration of lipoprotein, i.e., LDL & HDL before and after treatment1 1.In these studies it 1s suggested that low dose of aspirin (100 mg/day) may be of value in thrombotic condition ansi may act as anti1ipo proteinemic agent where the infrequent use of 300mg aspirin may be of no value.