Left Ventricular End-Diastolic Pressure and Extent of Coronary Artery Disease in Patients Undergoing Primary Percutaneous Coronary Intervention

Authors

  • Bashir Ahmed National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan
  • Khalil Ahmed Shaikh National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan
  • Jehangir Ali Shah National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan
  • Rajesh Kumar National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan
  • Kamran Ahmed Khan National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan
  • Mahesh Kumar Batra National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan
  • Ambreen Nisar National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan
  • Tahir Saghir National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan
  • Nadeem Qamar National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan

DOI:

https://doi.org/10.47144/phj.v56i3.2481

Abstract

Objectives: This study aimed to assess the association of left ventricular end-diastolic pressure (LVEDP) with the extent and severity of coronary artery diseases (CAD) in individuals undergoing primary percutaneous coronary intervention (PCI) at a tertiary care cardiac center in Karachi, Pakistan.

Methodology: This descriptive cross-sectional study included consecutive patients undergoing primary PCI. LVEDP was assessed with the help of a multipurpose catheter. The Association of LVEDP with the extent and severity of CAD was assessed.

Results: LVEDP was stratified as ≤15 mmHg, 15-25 mmHg, and >25 mmHg. Out of 498 patients included in this study, 76.3% (380) were male, and mean age was 53.7±11.7 years. Mean LVEDP was 19.35±6.17 mmHg. Burden of diseases was found to be significantly associated with LVEDP level (p<0.001) with mean LVEDP of 18.5±5.6 mmHg, 19.5±6 mmHg, and 21.4±7.2 mmHg among patients with single, two and three-vessel disease respectively. Proportion of three-vessel diseases was 15.5% (37/239), 22.5% (47/209), and 36% (18/50) at LVEDP ≤15 mmHg, 15-25 mmHg, and >25 mmHg, respectively.

Conclusion: There was a strong inverse relationship between LVEDP and initial TIMI flow grade (p=0.013) and a positive relationship between LVEDP and total length of the lesion (p=0.002). In conclusion, increased LVEDP was found to be associated with increased burden and extent of coronary artery disease, poor initial TIMI flow grade, and longer length of lesion.

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Author Biography

Tahir Saghir, National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan

 

 

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Published

2023-09-30

How to Cite

1.
Ahmed B, Shaikh KA, Shah JA, Kumar R, Khan KA, Batra MK, Nisar A, Saghir T, Qamar N. Left Ventricular End-Diastolic Pressure and Extent of Coronary Artery Disease in Patients Undergoing Primary Percutaneous Coronary Intervention. Pak Heart J [Internet]. 2023Sep.30 [cited 2024Nov.24];56(3):231-7. Available from: https://pakheartjournal1.pcs.org.pk/index.php/pk/article/view/2481

Issue

Vol. 56 No. 3 (2023): Pakistan Heart Journal

Section

Original Article

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Copyright (c) 2023 Pakistan Heart Journal

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