RESOLUTION OF LEFT ATRIAL THROMBUS IN SEVERE MITRAL STENOSIS PATIENTS AFTER THREE MONTHS OF ANTICOAGULATION

Authors

  • Fayaz Ali 1. National Institute of Cardiovascular Diseases (NICVD), Karachi-Pakistan
  • Kanwal Fatima Aamir National Institute of Cardiovascular Diseases, Rafiqui (H.J.) Shaheed Road, 75510, Karachi, Pakistan
  • Asif Nadeem Armed Forces Institute of Cardiology & National Institute of Heart Diseases (AFIC-NIHD), Rawalpindi-Pakistan
  • Rehmat Ghafar Hayatabad Medical Complex, Peshawar-Pakistan
  • Mahmood ul Hassan Hayatabad Medical Complex, Peshawar-Pakistan
  • Parveen Akhtar National Institute of Cardiovascular Diseases, Rafiqui (H.J.) Shaheed Road, 75510, Karachi, Pakistan
  • Samra Yasmin Haque Punjab Institute of Cardiology, Lahore-Pakistan
  • Shirjeel Murtaza Punjab Institute of Cardiology, Lahore-Pakistan
  • Fateh Ali Tipoo Aga Khan University Hospital, Karachi-Pakistan
  • Ishtiaq Rasool Fazaia Ruth Pfau Medical College, Karachi-Pakistan
  • Tariq Ashraf Karachi Institute of Heart Diseases, Karachi, Pakistan

DOI:

https://doi.org/10.47144/phj.v55i4.2327

Abstract

Objectives: To determine frequency of LA clot resolution in patients with severe MS after three months of anticoagulation.

Methodology: A descriptive study was conducted over 6 months from Jul 2018 to Jan 2019 including 49 patients who fulfilled the inclusion criteria and visited Cardiology department, NICVD Hospital-Karachi. After clinical evaluation, warfarin therapy was given for 3 months followed by Transesophageal echocardiography (TEE) to access the resolution of LA thrombus. Chi-square test and Fisher Exact test were used to assess the effect of patient characteristics and echocardiographic findings on the resolution of thrombus.

Results: The mean age of the study patients was 47.51±9.93 years. The average mitral valve area (cm2) was observed to be 0.68±0.16, while the average size of left atrial (mm) was 54.38±7.19. At the end of 2 months, TEE showed successful resolution of clot in 11 (22.4%). While by the end of 3 months, only 6 (12.2%) patients showed successful resolution of clot.

Conclusion: After 3 months of oral anticoagulation, the LA thrombus resolved in almost 1/4th of the study patients. Successful clot resolution showed positive correlation with history of stroke, hemoptysis and clot mobility and negative correlation with severity of tricuspid regurgitation.

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Published

2022-12-31

How to Cite

1.
Ali F, Aamir KF, Nadeem A, Ghafar R, ul Hassan M, Akhtar P, Haque SY, Murtaza S, Tipoo FA, Rasool I, Ashraf T. RESOLUTION OF LEFT ATRIAL THROMBUS IN SEVERE MITRAL STENOSIS PATIENTS AFTER THREE MONTHS OF ANTICOAGULATION. Pak Heart J [Internet]. 2022Dec.31 [cited 2024Sep.18];55(4):326-30. Available from: https://pakheartjournal1.pcs.org.pk/index.php/pk/article/view/2327

Issue

Vol. 55 No. 4 (2022): Pakistan Heart Journal

Section

Original Article

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Copyright (c) 2022 Pakistan Heart Journal

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