ASSOCIATION OF HYPERURICEMIA WITH THE PRESENCE AND SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY

Authors

  • Ammar Akhtar Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan
  • Muhammad Zubair Zaffar Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan
  • Rashid Minhas Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan
  • Hadi Yousuf Saeed Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan
  • Gul Zaman Khan Niazi Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan

DOI:

https://doi.org/10.47144/phj.v54i2.2092

Abstract

Objectives: To determine the association of hyperuricemia with the presence and severity of coronary artery disease in patients undergoing coronary angiography.

Methodology: This case control study was carried out in the Department of Cardiology, Chaudhary Pervaiz Elahi Institute of Cardiology, Multan for six months. Total number of 292  patients (146 cases with coronary artery disease and 146 controls with normal coronary arteries) having age 40-60 years of both genders were included in this study. Coronary angiography was performed using standard angiographic techniques. After undergoing coronary angiography, patients with 50% luminal stenosis or more in any one of the coronary arteries were labeled case group. Patients with normal coronaries or less than 50% luminal stenosis in any one of the coronary vessels were taken as control group. Serum uric acid was advised and value was noted along with the basic demographic data and established risk factors of coronary artery disease.

Results: Mean age was 50.79±6.08 years. Mean serum uric acid was 7.54±3.60 mg/dl. Hyperuricemia was diagnosed in 94 (64.40%) patients with significant CAD (case group) and in only 59 (40.40%) in control group. The odds ratio was 2.66 (95% CI 1.66 to 7.28) with p-value of <0.001. Triple vessel disease was diagnosed in 66.7% patients with hyperuricemia and in only 33.3% patients without hyperuricemia [OR 4.0 (2.09-7.64), p-value <0.001].

Conclusion: There is a significant association between the presence and severity of coronary artery disease with hyperuricemia.

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Published

2021-06-24

How to Cite

1.
Akhtar A, Zaffar MZ, Minhas R, Saeed HY, Niazi GZK. ASSOCIATION OF HYPERURICEMIA WITH THE PRESENCE AND SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY. Pak Heart J [Internet]. 2021Jun.24 [cited 2024Nov.24];54(2):157-61. Available from: https://pakheartjournal1.pcs.org.pk/index.php/pk/article/view/2092

Issue

Vol. 54 No. 2 (2021): Pakistan Heart Journal

Section

Original Article

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