PRO-INFLAMMATORY CYTOKINES INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR-a IN DIABETIC AND NON-DIABETIC MYOCARDIAL INFARCTION PATIENTS TREATED BY ANGIOPLASTY

Authors

  • Farhan Jaleel
  • Allah Bux Ghanghro
  • Saima Aqil
  • Muhammad Sameer Qureshi
  • Tariq Ashraf

DOI:

https://doi.org/10.47144/phj.v51i3.1532

Abstract

Objective: To evaluate the levels of pro-inflammatory cytokines Interleukin-6,Tumor necrosis factor-α before and after angioplasty in patients of myocardialinfarction with and without diabetes mellitus type II.

Methodology: This cross sectional study included patients between the age of 40and 60years presented to National Institute of Cardiovascular diseases, Karachi .Patients were divided into 2 groups. First group comprised of myocardialinfarction patients, second group included patients with myocardial infarctionand diabetes mellitus type 2. Serum Interleukin-6, Tumor Necrosis Factor-α,serum triglycerides, cholesterol, LDL cholesterol HDL cholesterol, FBS, HbA1Cand Insulin concentrations were determined. P value was determined byStudents t test. Chi Square test was applied to gender and smoking.

Results: We included 200 patients. The patients were divided into 2 groups andeach group comprised of 100 subjects. First group comprised of MyocardialInfarction patients, second group Myocardial Infarction with Diabetes Mellitustype 2 patients Values of fasting blood glucose, glycosylated hemoglobin andinsulin were significantly increased in myocardial infarction patients withdiabetes as compared with myocardial infarction patients without diabetes(p<0.001). Serum HDL cholesterol concentrations were significantly decreasedin myocardial infarction patients without diabetes (p<0.001) . When values ofcholesterol, triglycerides, LDL cholesterol, were compared, it was observed thatthey were non-significant. Interlekin-6 Tumor necrosis factor-α were found tosignificantly higher in both groups prior to angioplasty as compared with postangioplasty levels (p<0.001).

Conclusions: The study indicates that high levels of pro-inflammatory cytokinesare found at the time of ischemia which play an important role in the cascade ofMI. Levels were higher in patients regardless of diabetes mellitus status.

Key Words: Interleukin, Myocardial Infarction, Diabetes Mellitus, Inflammation,Coronary Angioplasty.

Downloads

Download data is not yet available.

Downloads

How to Cite

1.
Jaleel F, Ghanghro AB, Aqil S, Qureshi MS, Ashraf T. PRO-INFLAMMATORY CYTOKINES INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR-a IN DIABETIC AND NON-DIABETIC MYOCARDIAL INFARCTION PATIENTS TREATED BY ANGIOPLASTY. Pak Heart J [Internet]. 2018Nov.30 [cited 2024Nov.24];51(3). Available from: https://pakheartjournal1.pcs.org.pk/index.php/pk/article/view/1532

Issue

Vol. 51 No. 3 (2018): Pakistan Heart Journal

Section

Original Article

License

When an article is accepted for publication in the print format, the author will be required to transfer exclusive copyright to the PHJ and retain the rights to use and share their published article with others. However, re-submission of the full article or any part for publication by a third party would require prior permission of the PHJ.

Online publication will allow the author to retain the copyright and share the article under the agreement described in the licensing rights with creative commons, with appropriate attribution to PHJ. Creative Commons attribution license CC BY 4.0 is applied to articles published in PHJ https://creativecommons.org/licenses/by/4.0/